How to get rid of oral candidiasis and thrush?

There are several treatment options for mycoses. Soor, however, affects the little ones, so it is not advisable to apply topical ointments or gels intended for adults.

Even with home treatment, your pharmacist can recommend the right medication, so take advice and don't start treatment without professional consultation. The only freely available antifungal that can be used without fear in a newborn is gentian violet.

Table with recommended medicines:

Methylrosanilinium chlorides 2%

Methylrosanilinium chlorides 2%, also known as gentian violet, is a triarylmethane dye with antibacterial, antifungal and antihelmetic properties.

In the past, it has been used as one of the best antiseptic agents. Nowadays, it is gradually being replaced by other and more modern preparations, but it is still available on the markets. It is not tied to a prescription.

Interesting note: The reason gentian violet is being phased out of foods where it was previously found is because there have been papers published in the past that discuss the development of tumors in rodents with its frequent use. Even today, alarmist reports and unsubstantiated information sporadically appear on the Internet. However, there have never been any targeted studies to confirm or refute this claim.

Nystatin

Most often in newborns, drugs with the active substance nystatinare used. It is a fungicidal antifungal that can inhibit the further growth and multiplication of several species of fungi (Candida, Aspergillus, Rhodotorula, Torulopsis, Trichosporon).

Nystatin binds to ergosterol (part of the fungal plasma membrane), damaging it, leaking important substances, and killing the mycotic cell. Since human cells do not contain ergosterol, the drug is not harmful to them, except for possible allergic reactions.

It is used in the form of topical ointments (mucosal and skin mycoses) but also oral tablets (for fungal diseases of internal organs, e.g. intestine). It is also suitable for the treatment of vaginal mycoses in the form of vaginal laces.

Miconazole

The second, most commonly used substance is miconazole. It is a fungicidal antifungal that also kills some gram-positive bacteria. However, its use is only appropriate in children from 4 months of age. It is not recommended for younger children.

Interesting note: in children from 4 months of age, miconazole is used in the treatment of fungal diseases (soor). However, the lower age limit is increased by 1 to 2 months in premature infants in whom slow, neuromuscular development has been scientifically demonstrated to be related to the use of miconazole.

Miconazole, like nystatin, binds to ergosterol. It interferes with its biosynthesis (formation), resulting in the accumulation of reactive oxygen species in the cytoplasmic membrane region and methyl sterols and peroxides in the cytoplasm. The disruption of the membrane is severe and results in the arrest of growth of the mycotic cell.